Updated: May 12, 2020
Shea butter cannabis topicals help penetrate deep into your skin without entering the blood stream. Thus, no high - just pure skin/pain relief.
The invention relates to the technical field of medicinal materials, and in particular discloses use of shea butter as a transdermal osmosis promoter. Mouse skin stimulus and sensitization trials and in-vitro transdermal trials prove that the shea butter has a good transdermal osmosis effect, has a stronger transdermal osmosis capability compared with azone, does not irritate skin and sensitize, and can be used as the new transdermal osmosis promoter.
One kind of shea butter as the application of transdermal penetration enhancers
 The present invention relates to the technical field of pharmaceutical materials, particularly to an application of shea butter as a transdermal penetration enhancer. Background technique
 The transdermal delivery system (Transdermal Therapeutic System, referred to as TTS) refers to a controlled release formulation sky transdermal administration of systemic therapeutic effect. Destruction TTS system has unique advantages over the general method of administration, without passing through the liver “first pass effect” and the gastrointestinal tract, and to provide a predetermined longer duration of action, to maintain a stable, sustained plasma concentration, reduced time of administration, ease of administration and the like. However, the low transdermal absorption of drugs is a major disadvantage of this method of administration, limiting their broad application. Therefore, the development of new and effective transdermal penetration enhancers vital to promote the development of transdermal drug delivery formulations.
Study  permeation enhancer (Penetration Enhancer) began in 1970, Zellerbach and Miburn using dimethyl sulfoxide and dimethylacetamide to promote local administration of steroidal drugs patented. Current technology multi added Azone (Azone), propylene glycol (PG) and other penetration enhancers to increase the permeability of drugs and increase the permeation rate of drugs. Recent studies have found that certain natural ingredients and a similar role in promoting azone, since percutaneous penetration enhancer natural ingredients with rapid onset of effect, side effects, etc., so look for the transdermal penetration of the treasure from natural products agents are increasingly attracted people’s attention.
 The object of the present invention is to provide a shea oil as use of transdermal penetration enhancers, in particular shea butter as a medicament for transdermal application promoting penetration.
 shea butter, also known as shea butter, also translated as Shea butter is a natural non-toxic and non-irritating products. Shea is widely distributed in Africa and Guinea and other places, edible fruit, nuts are used to produce shea butter.Shea Butter indicators secretion of oil and human sebum closest, rich in unsaponifiable ingredients, easily absorbed by the human body, not only can prevent dry skin cracking, but also to further restore and maintain the skin’s natural elasticity, it has incredible deep moisturizing effect.
 GC-MS analysis using a fat component contained shea butter showed that seven major components and their weight percentages of shea butter are: lauric I. 589%, myristoyl Qu acid 3.075%, 70.286% palmitic acid, nonadecanoic O. 822%, 11- eicosenoic 3.958%, 16.506% arachidic acid, behenic acid I. 371%. Shea butter contained in the fat component can significantly increase the skin permeation of transdermal administration of the formulation, and has low toxicity and low skin irritation and so on.
 through the mouse skin irritation and sensitization test and in vitro experiments show that transdermal, shea butter has a strong effect of penetration enhancers, penetration enhancers which was significantly better than the ability of Azone, and non-irritating to the skin without sensitization can be used as a new transdermal penetration agent.